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Name: Timothy W Dolecek
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Question:
How do RNA nucleotides know what complementary bases to attach to in DNA?



Replies:
Nucleotides "match" each other by using the geometry of their molecules as well as by matching hydrogen bonds. An RNA adenine will have the proper shape as well as the proper number and position for forming hydrogen bond with a DNA thymine; an RNA cytosine will have the proper number of hydrogen bonds and the proper shape to fit a DNA guanine. Enzymes help with bringing the proper molecules together, just as they do when DNA is replicating.
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Ellen Mayo



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