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Name: Alexandre
Status: Student
Age: 20s
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Question:
I wanna know what is the etiopatogeny of Guillain-Barré Syndrome?



Replies:
Guillain-Barre Syndrome is a neurological disorder that causes periferal paralysis. It is believed to be antibody-mediated. The cause is a viral or bacteriological infection that results in an over-reaction of the immune system, leading to autoimmune response against the body-self gangliosides present on Schwann cells. One of the most common infections that can lead to GBS is Campylobacter jejuni, a Gram-negative bacterium that causes diarrhea and is a contaminant of poultry and other food-stuff. Fortunately, most Campylobacter infections do not lead to GBS, and possibly only certain serotypes are involved. Host factors certainly also determine if a C. jejuni infection, or a different infection, leads on to GBS (or the closely related Miller Fisher Syndrom) but we don't know what these host factors are. It has been proven that certain LPS structures on the surface of Campylobacter bacteria resemble the gangliosides present on neural cells.

A very good article on GBS is that of Nachamkin et al., J. Clin. Rev. 11, 555-567 (1998).

Dr. Trudy Wassenaar



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