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Name: Cecelia G.
Status: Other
Age: 60s
Location: N/A
Country: N/A
Date: 2002


Question:
What percentage of dog genes are shared with humans?



Replies:
Dear Cecilia:

According to the following article describing the AKC Canine Health Foundation and Ralston Purina Co. Fund Collaborative Gene Map Project, "the homology between the human and canine genome is over 85 percent.":

http://www.akc.org/love/dah/hn/genemap.cfm

Please bear in mind, however, that the Dog Genome Project is still in its early phases, as summarized by its web site from UC-Berkeley:

http://mendel.berkeley.edu/dog.html

More importantly, "homology" simply refers to the overall DNA sequence similarity. The actual "percentage of dog genes...shared with humans" is much more difficult to determine, although it's certainly in the realm of possibility within the near future, once mapping of both genomes has been completed. At the present time, I seriously doubt if this question could even be answered accurately for humans compared to mice, which have been much more extensively studied. However, based on their comparative evolutionary relatedness, I would guess that they are probably likely to share greater than 90% of their genes.

Thanks for the good question,

Jeff Buzby, Ph.D.
Children's Hosp. of Orange Cnty.
NEWTON AAS
Div. of Educational Programs
Argonne National Laboratory



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