Mitochondria and Apoptosis
Country: United States
Date: September 2006
How does damage to mitochondria DNA result in apoptosis, given the
understanding of the intrinsic pathway of apoptosis?
Any ideas? Would there be a good person I could ask this question too?
I only know that changes in Ca++ concentration in the cytosol, causes
cytochrome C to leak out of mitochondria which in turn activates a protease
that degrades proteins. If you do a search on google under "mitochondrial
apoptosis" you will get over 3 million hits.
Ron Baker, Ph.D
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Update: June 2012