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Name: Matt
Status: Student
Grade:  6-8
Location: N/A
Country: United States
Date: January 2007


Question:
Is it possible for a son to inherit an allele on an X chromosome from his father?



Replies:
The only ways a son could inherit an X chromosome from his father is if the father's genotype was 1) XXY, or 2) he was created from a sperm that had both an X and a Y in it.

1) There is a condition known as Klinefelter's Syndrome where a man has 3 sex chromosomes instead of 2 and he has an extra X. Most of the time these men are sterile however and would not be able to father a child. See #2 to learn how this condition is made.

2)Normally, males get their X from their mother and their Y from their father. There is a situation known as nondisjunction that occurs during anaphase I of meiosis, the time when one is making either eggs (if you are a woman) or sperm (if you are a man). This is the time when the parents' chromosomes are being divided in half, so that a new baby gets half its chromosomes from each parent. Usually, an equal number of chromosomes goes into each "half". Occasionally, one chromosome doesn't "let go" of its partner and they to one side or the other together. This results in one cell with too many chromosomes and another cell with too few. It is random which of these goes to make the baby. If this happens when the X and Y are being separated in the father and the child is made from the sperm that has both in it, the child could get an X from the father.

vanhoeck


The only way this could happen is if crossing over occurred between the X and Y chromosome in the father during meiosis, but this requires homolgous gene sequences between the X and Y chromosomes and I don't know of any genes that are located on both the X and Y chromosomes. That being said however, there must be some homology between the X and Y chromosomes since they do synapse during meiosis other wise the X and Y chromosomes would assort independently during meiosis which would result in 1/4 of the sperm carrying an X and a Y chromosome and 1/4 carrying neither an X nor a Y chromosome.

Ron Baker, Ph.D.



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