Viral Vaccine Determination
Date: Fall 2013
How do scientists know how to make a flu vaccine if viruses can be different every year?
Thanks for the question. For North America, usually the flu season is in winter. However, when it is summer in North America, it is winter in South America. By isolating and studying the flu viruses that are present in South America during their winter, scientists can determine which flu strains require vaccine development. So, flu vaccines are made from data collected during the winter in South America.
I hope this helps. Please let me know if you have more questions.
It's a very complicated process. Viruses usually begin in Asia and travel west around the world over the year. Scientists monitor and share information as to which viruses seem to be the most prevalent from year to year. Even though there may be many different strains, they must pick the 3 that appear to be the ones that will make the most people sick. They have about 9 months to predict and choose which strains will be put into the coming year's vaccine. Last year they were very happy with the ones they chose and said there was "good match" between the strains that were circulating in the US and the ones they predicted, yet the match was about 60%. This means that even if you got the vaccine, you could still get influenza if you caught one of the strains that wasn't in the vaccine.
Hope that answers your question.
The attached pdf file from this URL explains pretty clearly the process for developing flu vaccines.
Basically, its all educated guesswork. Scientists consider three candidate viruses that are most likely to be problematic during the flu season and develop a vaccine cocktail (trivalent vaccine) that confers protection to all three. Admittedly, the tendency of the influenza virus to mutate makes it difficult to stay one step ahead.
Dr. Tim Durham
Assistant Professor of Agronomy and Agricultural Science
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